Effect of Meditation on Intracerebral EEG in a Patient with Temporal Lobe Epilepsy: A Case Report

May 1, 2021
Arnaud Delorme, PhD

Delorme, A., Grandchamp, R., Curot, J., Barragan-Jason, G., Denuelle, M., Sol, J. C., & Valton, L. (2021). Effect of meditation on intracerebral EEG in a patient with temporal lobe epilepsy: A case report. EXPLORE17(3), 197–202.


Meditation has been deemed a miracle cure for a wide range of neurological disorders. However, it is unclear whether meditation practice would be beneficial for patients suffering from epilepsy. Here we report on the comparison of the effects of focused-attention meditation and a control task on electroencephalographic (EEG) activity in a patient undergoing stereoencephalographic (SEEG) investigation for drug-resistant epilepsy. The patient routinely practiced focused-attention meditation and reported that she found it beneficial. During the SEEG investigation, intracerebral EEG data were recorded during meditation as well as during mind-wandering task. The EEG data were analyzed for type of electrical activity (labeled) by two expert epileptologists. We found that the proportion of EEG segments containing activity classified as interictal epileptiform discharges (IEDs; abnormal electrical activity that occurs between seizures) increased significantly during meditation practice. Although the finding was surprising, this increase in IEDs may not correlate with an increase in seizure frequency, and the patient might still benefit from practicing meditation. The finding does, however, warrant further studies on the influence of meditation on epileptic activity.

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